The Study on the Expression of ICAM-1 in Transitional Cell Carcinoma of Bladder / 대한비뇨기과학회지

PURPOSE: ICAM-1(Intercellular Adhesion Molecule-1) is a cell adhesion molecule which facilitates the binding of LAK(Lymphokine Activated Killer )cell and cytotoxic T cell to tumor cell. This study investigates the role of ICAM-1 in transitional cell carcinoma(TCC) of bladder. MATERIALS AND METHODS: Immunohistochemical stain for ICAM-1 was done in 42 paraffin embedded tissue of primary TCC of bladder. And we compared the expression of ICAM-1 and the degree of immune cell infiltration, tumor grade, stage and survival rate of the patients. RESULTS: Immunohistochemical examination demonstrated expression of ICAM-1 on 17 of 42 bladder TCC but not on five normal transitional cells. The more frequently immune cells infiltrated, the more frequently ICAM-1 was expressed(p=0.018). And ICAM-1 was frequently expressed in higher histopathological grade and higher stage tumors(p=0.035, p=0.002). Survival rate was lower in ICAM-1 expressed tumors than in ICAM-1 non-expressed tumors even though it is insignificant statistically(p=0.11). CONCLUSIONS: These results suggest that ICAM-1 plays an important role on immune therapy for bladder TCC, and ICAM-1 expression in bladder TCC could be another prognostic factor and used as a response predictor for immune therapy such as intravesical BCG instillation.

A case of severely calcified leiomyoma of bladder / 대한비뇨기과학회지

Leiomyoma of the bladder is a rare. benign mesothelial tumor. Genitourinary leiomyoma may arise in any anatomic structure containing smooth muscle. A case of severely calcified leiomyoma or bladder is presented. Excretory urogram and computed tomogram suggested a bladder mass with calcification. The cystoscopic findings demonstrated intra-luminal protruding bladder mass with intact mucosa which suggested mesothelial calcified bladder tumor.

Experience of 191 Cases of Urethral Rupture and Stricture / 대한비뇨기과학회지

A clinical evaluation was made on 191 patients with urethral rupture and stricture, who had been admitted to the department of Urology during l3 years from l972 to 1984. We have tried the various methods in management of urethral rupture and stricture, such as 1) simple traction by balloon catheter 2) end-to-end anastomosis 3) perineal traction on the prostate 4) immediate cystostomy, and delayed urethroplasty in urethral rupture; 5) urethral dilatation 6) internal urethrotonry 7) end-to-end anastomosis 8) pull-through urethroplasty 9) transpubic urethroplasty 1O) scrotal inlay urethroplasty 11) perineal skin flap urethroplasty in urethral stricture. Especially, we have compared the primary realignment of urethral rupture with delayed urethroplasty Primary realignment with perineal traction on the prostate was most excellent in management of complete posterior urethral rupture, which had a low morbidity, complication, and cost. Immediate cystostomy, and delayed end-to-end anastomosis was good in management of complete anterior urethral rupture. We thought that the difference of result after primary. realignment or delayed urethroplasty of urethral rupture did not depend upon the alternative of them but the degree of urethral injury, surgeon's skill and the adequate application of them according to the state of patients at the time of urethral injury.

Experience of Gil Vernet Antireflux Surgery / 대한비뇨기과학회지

A new antireflux surgical technique was introduced by Gil Vernet in 1984, which is simple and rapidly accomplished without mobilization of the distal ureter. The technique involves a single stitch that implicates the trigone, effectively lengthening the intramural segment of terminal ureter, which is particularly effective in patients with megatrigone. We applied this new technique in 2 children with vesicoureteral reflux, of whom one had unilateral grade III reflux and the other bilateral grade II and grade IV reflux. Vesicoureteral reflux and urinary tract infection were lost at follow up voiding cystourethrogram and urinalysis 4 months after operation. We think that this new technique is excellent method in surgical treatment of vesicoureteral reflux.